Complement Ther Med. 2005 Dec;13(4):273-8. Epub 2005 Sep 9.
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Antihyperlipidaemic effect of a Monascus purpureus brand dietary supplement on a large sample of subjects at low risk for cardiovascular disease: a pilot study.
Cicero AF, Brancaleoni M, Laghi L, Donati F, Mino M.
Department of Internal Medicine and Applied Biotechnology, Atherosclerosis and Metabolic Diseases Study Centre G. Descovich, University of Bologna, S. Orsola-Malpighi University Hospital Via Massarenti, 9-40138 Bologna, Italy. afgcicero@cardionet.it
OBJECTIVES: We planned to carry out a pilot study to evaluate the efficacy and safety as an antihypercholesterolemic agent of a brand dietary supplement made of Monascus purpureus titrated extract, octacosanols and niacin on 111 Caucasian patients with low cardiovascular disease risk (<20% by Framingham algorithms), comparing them with the antihypercholesterolemic effect of a low dosage of Pravastatin on 20 subjects with similar risk profile. RESULTS: In our study, the tested dietary supplement determined a significant decrease of Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C), and Triglycerides (TG) in moderately hypercholesterolemic subjects without clinically relevant change in liver and muscular toxicity markers. The reduction of LDL-C reached the 20%, and it is similar to that obtained with a well-known effective statin like Pravastatin. CONCLUSIONS: Further long-term and double blind evaluation have to be carried out before to infer the observed results, however it appears that the studied dietary supplements could be a safe and efficacious antihypercholesterolemic agent for patients at low risk for cardiovascular diseases.
PMID: 16338198 [PubMed - indexed for MEDLINE]
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Niacin (Advicor®, Niacor®, Niaspan®) Niacin is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in your blood. Niacin is also used to prevent and treat pellagra (niacin defic...
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Pravastatin (Pravachol®, Pravigard® PAC) Pravastatin is used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount of cholesterol (a fat-like substance) and other fatty substances in the blood. Pravastatin is in a class of medicatio...
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